ABSTRACT Errors in handwritten prescriptions are a major factor in medical errors and are the main cause of harm to patients due to the lack of clarity of the prescription or the lack of correct data, which leads to the prescription of the wrong medication, causing adverse events. The present study aimed to identify the common errors in handwriting prescriptions in Zliten City. To collect information about errors in handwritten prescriptions, we used two models: first, we distributed fifty-one questionnaires to fifty-one pharmacies distributed in all areas of Zliten city, and second, we collected one hundred and fifty prescriptions from different health facilities distributed in different areas within Zliten city. The questionnaires and prescriptions then analysed to identify medical errors. In the first model of the questionnaire, the results are as follows: the patient's name and age are often present, while the gender, doctor's name, and stamp are often absent. The main issue lies in the clarity of the font for the drug's name, dose, and dosage form. In the second model of the prescriptions, the results are as follows: the patient's name is mostly present, while gender and diagnosis are absent in about 40% of the prescriptions, the doctor's name is mostly absent, and only 2% of the prescriptions have the doctor's stamp and number in the syndicate, and the main issue lies in the clarity of the font for the drug's name, dose, and dosage form., as it is unclear in between 20-30% of the prescriptions. We found that the patient's information is present in most prescriptions the opposite of the questionnaire in which it is less. Also in the prescriber's information, the analysis in our result for prescription contradicted the questionnaires, as most prescribers in the questionnaire are present, we also found that during the analysis of drug information in prescription not clear more than in the questionnaire. From this research, we concluded that there are many errors in prescriptions, possibly because of the large number of cases that need to be seen by the doctor and the speed of writing, and perhaps because doctors forget the vocabulary of the names of medicines. Because of the many errors in handwritten prescriptions, we must immediately switch to computerized prescription writing.

Keywords. Medical Prescription, Medical Errors, Prescription Errors.

Water injection has proven to be one of the most successful, efficient and cost-effective reservoir management strategies. By reinjecting treated and filtered water into tanks, this approach can help maintain tank pressure, increase hydrocarbon production, and reduce environmental impact. The goal of this project is to create a water injection model using Eclipse tank simulation software to better understand water injection methods to maintain tank pressure. A basic reservoir model is utilized in this investigation. The simulation was performed about 52 years using ECLIPSE Reservoir simulator. In all cases, result shows that oil production with water injection is higher compared with the base case. With this, it would be preferred to apply waterflooding for oil recovery in depleted reservoirs to the use of primary methods. It is also observed that water breakthrough is earlier and water production increases gently with water injection rates. Sensitivity on the injection rate using the 3D model showed that the injection rate has impact on the process. The pressure increases with high injection water rate in all cases. Despite higher reservoir pressure and early in water breakthrough, water flooding accounts for less oil recovery due to rapid water production. Generally, based on the results and discussions, it can be concluded that the water injection option can be used to increase the reservoir pressure to a good extent. 

Abstract::

The growing urgency for sustainable construction practices has necessitated a reevaluation of traditional design approaches in favor of more environmentally responsible methodologies. This paper presents a comparative analysis between optimal and adequate structural design within the context of sustainable construction. Focusing on two case studies—a cutting-edge, sustainably designed commercial building (the Bullitt Center) and a conventional mid-rise residential building in Chicago—the research explores how different design philosophies impact material efficiency, environmental footprint, economic performance, and occupant satisfaction.Through detailed life cycle assessments (LCA) and life cycle energy analyses (LCEA), the study quantifies the advantages of optimal design, which integrates advanced materials, renewable energy systems, and water conservation technologies. The findings demonstrate that while optimal design requires a higher initial investment, it significantly reduces long-term operational costs and environmental impact, achieving a net-zero energy status and greatly improving occupant well-being. In contrast, the conventional building, which adheres to standard design practices, exhibits higher embodied energy, greater environmental degradation, and lower occupant satisfaction.The paper concludes that optimal structural design is not only more sustainable but also economically viable over the building's life span. It emphasizes the importance of integrating sustainability from the earliest stages of design to achieve meaningful environmental and economic benefits. The study calls for the adoption of policy incentives and advanced modeling tools to facilitate the widespread implementation of optimal design principles in the construction industry.

Abstract:

Background: Oxidative stress is a key factor in the neurodegenerative disorder. Free radicals may play an important role. Nitric oxide may be implicated in neurotoxicity by a reaction with superoxide, which forms a highly toxic peroxynitrite radical.

Aim: This research aimed to investigate the role of nitric oxide in neuronal damage through Immunohistochemical study.

Material and method: The experiment was divided into 9 groups, each group containing 6 rats selected randomly. Group 1: control normal saline. Group 2: Aβ(1-42). Group 3: L-arginine. Group 4: L-NAME. Group 5: 7-nitroindazole Group 6: donepezil. Group 7: donepezil+ L-arginine. Group 8: donepezil+ L-NAME. Group 9: donepezil+7-nitroindazole. Neurotoxicity was induced by injection of Aβ(1-42) into the rat entorhinal cortex of all animals except the control normal saline group. After the end of the experiment brain was removed quickly for histopathological study.

Results: Aβ(1-42) significantly elevated COX-2 level when compared with control. when compared with Aβ treated rats, L-arginine, L-NAME, 7-nitroindazole and donepezil separately did not improve the changes in COX-2 level. The combination of donepezil with 7-NI is back to normal.

Conclusion: we concluded that NO plays a central role in neurotoxicity and the regulation of NO level is the key to stability and prevention of neurodegenerative disorder.

Keywords: Oxidative stress, Neuroinflammation, Beta amyloid, L- NAME, Donepezil, L-arginine, Nitric oxide, 7-nitroindazole.