ABSTRACT Coronary artery disease (CAD) is quite common among diabetics in all age groups and its risk is independently affiliated with Lipoprotein-associated phospholipase A2 (LP-PLA2). There is strong evidence that the elevated plasma level of Lp-PLA2 indicates vascular inflammation associated with plaque formation within the arteries. Therefore, the relationship between the plasma Lp-PLA2 level and coronary

artery disease risk factors between non-diabetic and diabetic patients will be studied. Materials and Methods: A total of 181 individuals were recruited from the National Heart Centre Tajoura and divided into 4 groups (40 healthy controls (HC), 43 non-diabetics (NDM) who had CAD, 54 DM2 without CAD, and 44 DM2 who had CAD). The relationship between Lp-PLA2 and the potential biochemical risk markers for CAD will be studied between the groups. Results: All the groups that participated in this study have similar body mass index. There is statistical significance in the level of plasma level Lp-PLA2 between DM2 with CAD, DM2 without CAD and HC with ( ***P<0.0001, **P<0.006), respectively; and likewise between NDM with CAD and HC with *P<0.05. Although there is a significant difference between the plasma levels of Lp-PLA2 between the groups below the age of 60 years, there is no statistical significance between the groups above the age of 60 years. Correspondingly, there is a statistical difference in the plasma level of Lp-PLA2 between healthy controls and both DM2 without CAD and DM2 with CAD with (**P<0.006, and ***P<0.0001), respectively. Once more, there is statistical significance in the plasma level of Lp-PLA2 between NDM with CAD and healthy controls with *P<0.05. Furthermore, there is a statistical difference in the serum level of CRP between DM2 with CAD and HC. In addition, there is a positive relationship exists between the duration of diabetes mellitus without CAD and the level of glycated haemoglobin (HbA1c) with **P <0.003 in both genders. Conclusion: In this study, the high level of Lp-PLA2 and CRP strongly indicate the presence of vascular inflammation associated with the formation of arterial atherosclerosis with thrombus formation. These findings are also correlated with diabetic duration and they could be used in the diagnosis and prognosis of coronary artery disease. 

In this study, bovine sodium caseinate (NaCas) was hydrolyzed with four proteases, alcalase, savinase, subtilisin A, and flavourzyme. In addition to the structural changes occurred through the enzymatic hydrolysis, the solubility, oil binding capacity, zeta potential, emulsification properties, and in vitro antioxidant capacity, anti-carcinogenic and antidiabetic properties of hydrolysates were determined. FTIR combined with hierarchical cluster analysis (HCA) made in Amide I region

enable to classification of the samples based on the changes of the secondary structure depending on the enzyme type and degree of fragmentation. Technological properties of NaCas were enhanced through the enzymatic hydrolysis, and those were more prominent in serine-type enzymes, regardless of the enzyme type, all hydrolysates showed high antioxidant capacities. All

hydrolysates, specifically those produced by savinase and alcalase, reduced the viability of the carcinogenic Caco-2 cells in a dose-dependent manner and showed a very low level of cytotoxicity against healthy HEK-293 cells. The hydrolysis treatment made a significant contribution to the antidiabetic activity of NaCas. Particularly alcalase and savinase hydrolysates suppressed the activity of a- amylase and a- glucosidase. Therefore, the generated milk protein hydrolysates could be used

in functional food developments for specific dietary purposes.

The pandemic had a significant impact on the physical and mental health of the world population. In this context, higher levels of negative and positive symptoms related to psychosis have been observed. The present study aimed to verify, through a systematic review and meta-analysis, the evolution of negative and positive symptoms of schizophrenia during the pandemic period. 

The present work adhered to the PRISMA guidelines, and the GRADE and New Castle Ottawa bias scales were applied. Longitudinal studies from 2020-2021 that assessed negative and/or positive symptoms in persons diagnosed with schizophrenia before and during the pandemic period were searched on PubMed, PsycInfo and PsycArticles. The main results showed significant differences between the pre and the pandemic period regarding negative symptoms [95% CI -0.47 (-0.70, -0.24); Z = 4.01 (p < 0.0001)]. In conclusion, the work showed a worsening of negative symptoms during the pandemic in persons with schizophrenia. The results suggested the importance, in the post-pandemic period, of planning psychosocial interventions for these individuals.

Shaping of the conductor or any of the other parts of the patch radiators plays important role in changing the working parameters of this type of antennas. In this work Annular, shape has been introduced on the conductor patch. Different dimensions have been introduced on the annular geometry and with a help of a simulation package obtained results are dependable on for application in microwave frequency ranging from 2.5 GHz to 5 GHz. Encouraging values of Bandwidth have been obtained with reasonable output of return loss

This paper presents the design and simulation of a microstrip array patch antenna operating at 28 GHz for 5G communication with a maximum reflection coefficient of -17 dB, a very wide bandwidth of 1.5 GHz and a high gain of 6.84 dB. A Roger RT5880, which has a dielectric constant of 2.2 and a height of 0.2 mm has been used as a transmission line with an inset feed. Antenna dimensions were calculated and simulated results have been performed and analyzed using CST Microwave Studio Package. Moreover, linear array with 3x1 and 5x1, to provide better gain to reach 13 dB and reducing the mutual effect, was developed using decoupling simple slab techniques.

This research presents patch antenna design that enhances its performance to work in 5G band with: sufficient bandwidth, acceptable insertion loss level and effective gain value. A selective procedure for finding suitable patch height has been undertaken. Parallel to this a technique of inserting appropriate Rectangular back holes in substrate has been also made. A simulation program using recent version of the well-known HFSS has been used for obtaining best of results. Sufficient bandwidth values in the range of (27 - 29.39)GHz with return loss range( -15dB - -33dB) have been obtained with acceptable gain value.