This study critically examines the short- and long-term linkages between foreign trade volume (TVR) and sustainable development (SD) in Libya’s unique post-conflict, resource-dependent economy over the period 1990–2022. Utilising autoregressive distributed lag (ARDL) modelling, it assesses TVR’s impact on Hickel’s Sustainable Development Index (SDI) a holistic metric that goes beyond GDP by integrating crucial environmental and human well-being indicators. The results reveal a positive long-term cointegration between TVR and the SDI, primarily driven by associated growth in GDP and GDP per capita. However, this relationship remains fragile, as persistent inflation and high unemployment significantly undermine sustainability gains. Libya’s structural overreliance on hydrocarbons and chronic macroeconomic instability are identified as the core impediments to balanced progress. The study recommends a strategic pivot towards diversifying exports, stabilising macroeconomic conditions, and implementing fair labour policies to better align trade growth with the Sustainable Development Goals (SDGs). Prioritising inflation control and fostering inclusive employment are paramount to enhancing Libya’s SDI resilience.

The global pandemic Coronavirus Disease 19 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Many patients with life-threatening illness due to COVID-19 die from hypoxic respiratory failure, which appears to be related to a cytokine storm syndrome leading to Acute Respiratory Distress Syndrome (ARDS). While steroids have some demonstrated benefits, supportive care remains the mainstay of treatment. However, in the absence of vaccines and proven treatments, during this current pandemic, we are considering repurposing currently available medications; one of the first is cotrimoxazole (CTX), which was one of the earliest medications for treating and preventing opportunistic infections caused by the human immunodeficiency virus (HIV), among other things. Cotrimoxazole in combination with folic acid is inexpensive, familiar to the public, and generally well tolerated, and treats secondary infections. Low cost and a good safety profile can make it an ideal candidate for the treatment of COVID-19 in a low-resource country like Libya. Here we report our observations with cotrimoxazole added to standard therapy in patients with severe COVID-19. Prospective data were gathered from consecutive newly diagnosed patients who presented to the Msallatah Isolation Center (Corona Center), Msallatah, Libya, between June and September of 2021 with critical COVID-19 on non-invasive ventilation and receiving standard therapy (ST) along with 480 mg oral cotrimoxazole (CTX). The first four days served as a control period during which patients with critical COVID-19 received only standard treatment. After a 4-day control period during which the patients received ST alone, nine patients (mean age ± SEM 40.5 ± 10.5 years, 66.66 percent male) were identified because they received CTX in addition to ST. We found that patients with critical COVID-19 who received CTX in addition to ST experienced significantly better outcomes, such as lower in-hospital mortality (0%), higher blood levels of D-Dimer (3735±579.9 mg/L versus 444.82±182.14 mg/L, p˂0.05), and improvements in respiratory rate (36.42±3.9 mg/L versus 25.6±2.9 mg/L, p˂0.05) and CRP at the fourth day of the experiment (142.12±34.7 mg/L versus 72.4±19.26 mg/L, p˂0.05). These results demonstrate the beneficial effects of using cotrimoxazole in patients with severe COVID-19; it could help to reduce the need for respiratory support for thousands of patients, saving valuable lives and decreasing the burden on the healthcare system in countries with limited resources. The mechanism of action of cotrimoxazole in this situation is not clear; however, these outcomes may be due to the antibiotic activity and/or the anti-cytokine effects of cotrimoxazole. Further trials are needed to test our observations.

Thin films deposited on glass surfaces can be produced by various

methods, including physical methods (thermal evaporation in

vacuum, sputtering, etc.) and chemical methods (chemical

deposition, chemical vapor deposition, thermal chemical analysis,

etc.). In this paper, thin films were deposited on glass slides using

the plasma-enhanced chemical vapor deposition (PECVD)

technique at pressures (10,30 and 50 mTorr) for varying durations

of (5,10 and 15 minutes). In addition, the results indicates that

increasing the deposition time significantly influenced the film

thickness while the adhesion does not directly depend on time.

Asphalt roads are one of the most important elements of infrastructure in any country, as they play a vital role in achieving comprehensive development and economic growth. They provide safe and reliable means of transportation for citizens and companies, which develops trade, contributes to the development of industry, and expands the investment base. In addition, asphalt roads contribute to enhancing tourism and developing the infrastructure of cities and rural areas. Therefore, it is necessary to invest heavily in the construction and maintenance of asphalt roads to ensure economic growth and social stability. The Superpave system is an important development in the field of paving, as it contributes to improving the design of hot asphalt mixes and evaluating the performance of paving facilities. This system relies on precise standards to evaluate the quality of asphalt mixes, which leads to improving the durability of the pavement and its efficiency in withstanding different traffic loads. This system is also the result of field and laboratory research and studies included in the Strategic Highway Research Program in the United States of America. Due to the importance of this system, we present this study to examine previous studies on the classification of asphalt binders in the high-performance asphalt paving system (Superpave) and to identify the significance of classifying the binder in this system.

A recent years. They have evolved into analysis of tumor Abstract— Multiplexed platforms have become a standard feature of modern medicine in the field of histopathology in recent years. They have evolved into powerful technologies that enable image analysis of tumor tissues from formalin- fixed paraffin- embedded specimens, aiming for better assessment of morphology and distinctive alterations at the molecular level of the patient’s sample, which is critical for the pathologist’s diagnosis and classification, with significant implications for the following therapeutic options. And also, in order to gain a better understanding of the tumor microenvironment, which aids cancer prevention by simulating new therapy discoveries. And unlike traditional IHC, which can only identify one marker in a tissue sample, multiplex IHC may detect many markers in a single tissue sample while providing detailed information about the cell composition and spatial arrangement. Reviewing multiplexed technologies is to demonstrate their utility in the study of cancer tissue as well as their benefits for applications in cancer diagnosis, stratifying patients, and accuracy for treatment. Summary: Digital pathology plays a significant part in current clinical practice and becoming an increasingly critical technological necessity in the laboratory environment, Algorithms for image analysis and artificial intelligence have the potential to further increase the quality of diagnostics in pathology. Keywords— Digital pathology; Molecular diagnostics; IHC & MIHC Techniques; cancers.