Introduction: Diabetes is a common condition among pregnant women, and a high glycated haemoglobin (HbA1c) level can indicate poor outcomes for both the mother and the fetus. This report presents a case of an unknown diabetic primigravida with a significantly elevated HbA1c level, which resulted in severe complications during pregnancy and adverse fetal outcomes. Case Study: A 37-year-old primigravida was referred to the emergency obstetrics and gynaecology clinic, where she reported a notable decrease in fetal movements and feelings of lethargy. Laboratory tests revealed a significantly elevated blood sugar level. After assessing fetal well-being, the decision was made to terminate the pregnancy at 33 weeks and 2 days due to severe fetal distress. Immediate treatment was initiated to control the high blood sugar levels. The outcome was the delivery of a preterm boy who presented with multiple biochemical imbalances and required admission to the neonatal intensive care unit (NICU). Conclusion: Improving hyperglycemia and glycated haemoglobin levels to lower than the upper normal limits during both the preconception and post-conception phases can significantly reduce morbidity and mortality for mothers and their fetuses.

Eighty-five rock samples corresponding to the Palaeozoic formations were taken from two wells in

the NC 200 Block of the Murzuq Basin. The study aimed to find out geochemical characteristics of

parameters and specific Gas Chromatography-Mass Spectrometry (GC-MS) biomarkers were 

applied to determine the potential hydrocarbon generation. Per se, Rocks are good sources and 

hold fair content of organic matter, crossing in the range of good accumulation, in which the very 

good source rocks have an organic carbon richness (TOC) reached of 3.7 wt%. The studied rocks 

are ranged from immature to late mature organic matter (OM) with total organic carbon richness 

(TOC) range between 0.4 – 3.7 wt%. Rock-Eval parameters S1, S2, S3, Tmax, S2/S3, OI, PI and HI 

of the source rock samples have values ranged from 0.02 – 0.3, 0.22 – 6, 0.36 – 4, 423 – 443, 24= 

350, 0 – 0.27 and 42 – 384 respectively. The range of hydrogen index (HI) related to oxygen index 

(OI) displays that all kerogen types from Type II to Type III are exist and increase with depth. The 

Tmax parameter is wide-ranging among studied formations, indicating different levels of organic 

matter maturity, from immature oil window and to late mature for the Devonian-Carboniferous and 

Silurian source rocks, associated with more depth. Molecular composition analysis of n-alkanes and 

other biomarkers supported the findings of Rock-Eval pyrolysis data, revealing varied hydrocarbon 

signatures across the formations. The Carbon isotope analysis (δ13C) suggested multiple sources 

contributing to the generated oil, including Type I to Type III kerogens. Silurian Bir Tlacsin/Tanezzuft Formations, the Devonian Awaynat Wanin/BDS II Formations, and

Large outbreaks of skin lesions in cattle have been observed recently throughout the governorate. The LSDV was

shown to be the causative factor. The local strain of LSDV was sequenced and deposited into GenBank, where it

was assigned the accession number MK552139 and designated as LSDV/Egy-BSU/2018. The discovered strain

resources were connected and to other LSDVs, however the phylogenetic tree clustered viruses of sheep pox, goat

pox, and LSD viruses independently.

Abstract::

The growing urgency for sustainable construction practices has necessitated a reevaluation of traditional design approaches in favor of more environmentally responsible methodologies. This paper presents a comparative analysis between optimal and adequate structural design within the context of sustainable construction. Focusing on two case studies—a cutting-edge, sustainably designed commercial building (the Bullitt Center) and a conventional mid-rise residential building in Chicago—the research explores how different design philosophies impact material efficiency, environmental footprint, economic performance, and occupant satisfaction.Through detailed life cycle assessments (LCA) and life cycle energy analyses (LCEA), the study quantifies the advantages of optimal design, which integrates advanced materials, renewable energy systems, and water conservation technologies. The findings demonstrate that while optimal design requires a higher initial investment, it significantly reduces long-term operational costs and environmental impact, achieving a net-zero energy status and greatly improving occupant well-being. In contrast, the conventional building, which adheres to standard design practices, exhibits higher embodied energy, greater environmental degradation, and lower occupant satisfaction.The paper concludes that optimal structural design is not only more sustainable but also economically viable over the building's life span. It emphasizes the importance of integrating sustainability from the earliest stages of design to achieve meaningful environmental and economic benefits. The study calls for the adoption of policy incentives and advanced modeling tools to facilitate the widespread implementation of optimal design principles in the construction industry.

Abstract:

Background: Oxidative stress is a key factor in the neurodegenerative disorder. Free radicals may play an important role. Nitric oxide may be implicated in neurotoxicity by a reaction with superoxide, which forms a highly toxic peroxynitrite radical.

Aim: This research aimed to investigate the role of nitric oxide in neuronal damage through Immunohistochemical study.

Material and method: The experiment was divided into 9 groups, each group containing 6 rats selected randomly. Group 1: control normal saline. Group 2: Aβ(1-42). Group 3: L-arginine. Group 4: L-NAME. Group 5: 7-nitroindazole Group 6: donepezil. Group 7: donepezil+ L-arginine. Group 8: donepezil+ L-NAME. Group 9: donepezil+7-nitroindazole. Neurotoxicity was induced by injection of Aβ(1-42) into the rat entorhinal cortex of all animals except the control normal saline group. After the end of the experiment brain was removed quickly for histopathological study.

Results: Aβ(1-42) significantly elevated COX-2 level when compared with control. when compared with Aβ treated rats, L-arginine, L-NAME, 7-nitroindazole and donepezil separately did not improve the changes in COX-2 level. The combination of donepezil with 7-NI is back to normal.

Conclusion: we concluded that NO plays a central role in neurotoxicity and the regulation of NO level is the key to stability and prevention of neurodegenerative disorder.

Keywords: Oxidative stress, Neuroinflammation, Beta amyloid, L- NAME, Donepezil, L-arginine, Nitric oxide, 7-nitroindazole.

ABSTRACT: Study area situated in the center of the Hameimat trough which is located in the southeast of the Sirte basin. The Hameimat trough contains two of the largest oil fields in Libya, Gialo and Abu-Attifel fields. The Upper Cretaceous Rachmat, Tagrifet, and Sirte Formations are considered as the main source rock in Sirte Basin.Organic geochemical study of the Upper Cretaceous Rachmat, Tagrifet and Sirte Formations show these Formations have total organic carbon content values of 0.53% to 3.35% fair to excellent as source rock. The Kerogen types are type II and III mixed continental and marine organic matter. The thermal maturity of these formations indicates a mature stage in oil window.Oil saturation index (OSI: S1*100/TOC) shows that Sirte and Rachamt formations have low oil saturation, while the Tagrifet formation has good potential, where OSI exceeds 140 mg HC/g TOC in the most samples of the formation. The Tagrifet formation considers a good unconventional reservoir for shale oil, where the Sirte and Rachmat formations consider possible for shale oil with high risk.

Keywords: Unconventional reservoirs, Organic geochemistry, Sirte basin, shale oil and gas