The aesthetic performance of zirconia restorations depends greatly on their optical properties, particularly translucency, which can be influenced by various chemical exposures in the oral environment. This in vitro study aimed to evaluate the effect of different immersion solutions on the translucency of two types of zirconia materials. A total of 30 zirconia specimens (n = 15 per group) were prepared: Group A comprised monolithic zirconia, while Group B consisted of multilayered yttria-stabilized zirconia. Each group was divided into three subgroups (n = 5) and immersed in one of three solutions: distilled water (DW), chlorhexidine (CHX), or 0% alcohol mouthwash. Translucency parameters (TP) were measured before and after immersion using a spectrophotometer based on the CIELab system. Statistical analysis was conducted using GraphPad Instat software with significance set at p < 0.05. The results revealed that immersion in CHX caused the most significant increase in TP change in both groups, with monolithic zirconia (Group A) showing the highest overall change. Two-way ANOVA indicated that the immersion solution had a statistically significant effect on translucency (p < 0.0001), while the type of zirconia showed no significant main effect (p = 0.0779). These findings suggest that translucency changes are more dependent on the immersion media than the zirconia composition itself. Clinicians should consider the long-term aesthetic implications of chemical exposure on zirconia restorations, especially when prescribing disinfectant mouthwashes. 

Asphalt roads are one of the most important elements of infrastructure in any country, as they play a vital role in achieving comprehensive development and economic growth. They provide safe and reliable means of transportation for citizens and companies, which develops trade, contributes to the development of industry, and expands the investment base. In addition, asphalt roads contribute to enhancing tourism and developing the infrastructure of cities and rural areas. Therefore, it is necessary to invest heavily in the construction and maintenance of asphalt roads to ensure economic growth and social stability. The Superpave system is an important development in the field of paving, as it contributes to improving the design of hot asphalt mixes and evaluating the performance of paving facilities. This system relies on precise standards to evaluate the quality of asphalt mixes, which leads to improving the durability of the pavement and its efficiency in withstanding different traffic loads. This system is also the result of field and laboratory research and studies included in the Strategic Highway Research Program in the United States of America. Due to the importance of this system, we present this study to examine previous studies on the classification of asphalt binders in the high-performance asphalt paving system (Superpave) and to identify the significance of classifying the binder in this system.

A recent years. They have evolved into analysis of tumor Abstract— Multiplexed platforms have become a standard feature of modern medicine in the field of histopathology in recent years. They have evolved into powerful technologies that enable image analysis of tumor tissues from formalin- fixed paraffin- embedded specimens, aiming for better assessment of morphology and distinctive alterations at the molecular level of the patient’s sample, which is critical for the pathologist’s diagnosis and classification, with significant implications for the following therapeutic options. And also, in order to gain a better understanding of the tumor microenvironment, which aids cancer prevention by simulating new therapy discoveries. And unlike traditional IHC, which can only identify one marker in a tissue sample, multiplex IHC may detect many markers in a single tissue sample while providing detailed information about the cell composition and spatial arrangement. Reviewing multiplexed technologies is to demonstrate their utility in the study of cancer tissue as well as their benefits for applications in cancer diagnosis, stratifying patients, and accuracy for treatment. Summary: Digital pathology plays a significant part in current clinical practice and becoming an increasingly critical technological necessity in the laboratory environment, Algorithms for image analysis and artificial intelligence have the potential to further increase the quality of diagnostics in pathology. Keywords— Digital pathology; Molecular diagnostics; IHC & MIHC Techniques; cancers. 

Abstract

Gall bladder cancers, predominantly adenocarcinomas, are associated with significant malignancy and are more common in women, especially in their seventh decade of life. This study aims to evaluate the prevalence, distribution, and histopathological characteristics of gall bladder tumors, emphasizing the need for early diagnosis and understanding the role of chronic cholecystitis in tumor development. A retrospective analysis was performed on 45740 surgical biopsies, including 3107 cholecystectomies, from 1994 to 2007 at Misurata Medical Center, Libya. Data collected included patient demographics, clinical details, and microscopic diagnoses. Biopsy samples were processed and stained, and histopathological evaluation was performed following standard criteria. The study showed a female predominance in gall bladder tumors with a female: male ratio of 3:1. Most tumors were adenocarcinomas (83.33%), with high and moderate differentiation being the most frequent. Tumor diagnoses were most prevalent in the 51-65 age group. The majority of tumors were diagnosed at advanced stages (3 and 4). Tumor invasion was common, with 75% showing perivascular, intravascular, or perineural involvement. Chronic cholecystitis was observed in more than two-thirds of the tumor cases. Chronic inflammation is closely linked to gallbladder carcinogenesis, with most tumors diagnosed at advanced stages due to vague symptoms and aggressive behavior. Early detection and multidisciplinary approaches are vital to improve outcomes, especially in high-risk groups.

Abstract

Microscopic diagnosis of gastrointestinal biopsies remains a challenge in surgical pathology, involving both neoplastic and non-neoplastic changes. This study aims to analyze the prevalence, histopathological features, and grading of gastrointestinal (GIT) tumors in biopsies collected over 12.5 years at Misurata Medical Center, Libya, while assessing demographic patterns and the correlation of Helicobacter pylori infection with gastric malignancies. A total of 753 GIT biopsies were retrospectively analyzed from 1995 to 2007. Clinical data, including age, sex, and microscopic diagnoses, were documented. Biopsies underwent histopathological evaluation using the World Health Organization (WHO) classification. Statistical analyses were performed using SPSS software to explore relationships between neoplastic lesions and demographic factors. Non-neoplastic diseases accounted for 559 cases, which constitute 74.24% of the total cases, while neoplastic lesions were identified in 194 cases (25.76%). with a statistically significant predominance of malignant tumors (68.6%) over benign ones (31.4%, p<0.001). A slight male predominance was observed in overall biopsies (52.2%), with the 61-70 age group showing the highest frequency (17.4%). Well-differentiated tumors were more common, correlating with better prognoses. The TNM staging analysis revealed a concerning trend toward late-stage diagnoses, particularly in stomach and colorectal cancers. The investigation into Helicobacter pylori positivity indicated a complex relationship with gastric malignancies, warranting further research. The findings reflect a high burden of GIT malignancies during the study period, with late-stage diagnosis and limited diagnostic resources. These results underscore the need for improved screening programs, early detection efforts, and enhanced diagnostic infrastructure in Libya. The study underscores the importance of understanding the multifactorial influences of Helicobacter pylori in gastric cancer development.